Many prescription and nonprescription medicines can cause breast problems, such as breast tenderness or nipple discharge. A few examples are:

• Some antidepressants.
• Some blood pressure medicines.
• Corticosteroids, such as prednisone.
• Medicines that contain hormones, such as birth control pills, hormone therapy, and infertility medicines.
• Migraine headache medicines, such as sumatriptan.

Cimetidine, such as Tagamet, may cause nipple discharge and breast enlargement in men.